https://nova.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:41157 Wed 15 Feb 2023 10:57:18 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:30189 Hfe^−/−xTfr2^mut mouse model. This was accompanied by altered expression of a group of myelin-related genes, including a suite of genes causatively linked to the rare disease family ‘neurodegeneration with brain iron accumulation’ (NBIA). Expanded data mining and ontological analyses have now identified additional myelin-related transcriptome changes in response to brain iron loading. Concordance between the mouse transcriptome changes and human myelin-related gene expression networks in normal and NBIA basal ganglia testifies to potential clinical relevance. These analyses implicate, among others, genes linked to various rare central hypomyelinating leukodystrophies and peripheral neuropathies including Pelizaeus-Merzbacher-like disease and Charcot-Marie-Tooth disease as well as genes linked to other rare neurological diseases such as Niemann-Pick disease. The findings may help understand interrelationships of iron and myelin in more common conditions such as hemochromatosis, multiple sclerosis and various psychiatric disorders.]]> Wed 11 Apr 2018 16:58:00 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:15120 Wed 11 Apr 2018 14:37:46 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:29574 Wed 11 Apr 2018 14:11:09 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:22222 10 g/dl) and normocytic. There was an increased risk of death from all causes and from cancer for men with low haemoglobin. Cancers were predominantly of the prostate and genito-urinary organs, and to a lesser extent the gastrointestinal tract. There was no increased risk of all cause or cancer death in women. Conclusion: mild, normocytic anaemia is associated with survival reductions in middle-aged and older men, where it often occurs with prostate, gastrointestinal and other cancers, and should be investigated to exclude treatable causes.]]> Wed 11 Apr 2018 12:10:33 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:4605 .05). Conclusion: Noncitrus fruits are environmental modifiers of iron status independent of HFE genotype. This could have important implications for the provision of evidence-based dietary advice to patients with other iron-storage disorders.]]> Wed 11 Apr 2018 09:47:07 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:28613 Wed 11 Apr 2018 09:21:51 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:31006 Wed 02 Mar 2022 14:28:48 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:32708 Tue 05 Mar 2024 15:32:09 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:45342 Thu 27 Oct 2022 15:17:41 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:32703 Thu 12 Jul 2018 11:51:28 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:32702 Thu 12 Jul 2018 11:51:24 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:31487 Sat 24 Mar 2018 08:43:40 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:7033 Sat 24 Mar 2018 08:37:51 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:1596 Sat 24 Mar 2018 08:30:41 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:1370 Sat 24 Mar 2018 08:28:21 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:1747 Sat 24 Mar 2018 08:27:24 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:12514 Sat 24 Mar 2018 08:17:39 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:10663 Sat 24 Mar 2018 08:12:41 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:10312 0.05). In participants without dementia (n=749), neither serum ferritin in 1994/5 or 2003/4 nor change in serum ferritin between these times was related to total CAMCOG or executive function scores, with or without adjustment for gender, age, National Adult reading test, or stroke history (all p> 0.05). No relationships were observed between ferritin and cognition for participants with possible or probable dementia (n=51). All participants identified as HFE C282Y homozygous or with serum ferritin >1,000 ng/ml had normal CAMCOG scores. We conclude abnormal body iron stores (low or high) are unlikely to have clinically significant effects on cognition or dementia risk in community-dwelling older people.]]> Sat 24 Mar 2018 08:12:22 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:10036 Sat 24 Mar 2018 08:12:16 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:10807 Sat 24 Mar 2018 08:11:50 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:10479 Sat 24 Mar 2018 08:09:15 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:20882 -/- mice, a model of hemochromatosis, relative to age- and gender-matched wildtype controls. Classification by functional pathway analysis revealed transcript changes for various genes important in AD. There were decreases of up to 9-fold in transcripts for amyloid-β protein precursor, tau, apolipoprotein E, presenilin 1, and various other γ-secretase components, as well as Notch signaling pathway molecules. This included decreased transcripts for 'hairy and enhancer of split' Hes1 and Hes5, downstream targets of Notch canonical signaling. The reductions in Hes1 and Hes5 transcripts provide evidence that the changes in levels of transcripts for γ-secretase components and Notch signaling genes have functional consequences. The effects appeared relatively specific for AD in that few genes pertaining to other important neurodegenerative diseases, notably Parkinson's disease and Huntington's disease, or to inflammation, oxidative stress, or apoptosis, showed altered transcript levels. The observed effects on AD-related gene transcripts do not appear to be consistent with increased AD risk in HFE hemochromatosis and might, if anything, be predicted to protect against AD to some extent. As Hfe^-/- mice did not have higher brain iron levels than wildtype controls, these studies highlight the need for further research in models of more severe hemochromatosis with brain iron loading.]]> Sat 24 Mar 2018 07:57:56 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:17878 Sat 24 Mar 2018 07:56:13 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:5556 Sat 24 Mar 2018 07:49:12 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:25111 Sat 24 Mar 2018 07:17:15 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:24321 Sat 24 Mar 2018 07:14:41 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:38383 Mon 29 Jan 2024 17:45:07 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:32706 Mon 23 Sep 2019 11:46:16 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:32298 Mon 23 Sep 2019 11:17:56 AEST ]]>